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Filtered Search Results
Selleck Chemical LLC SU11274 S1080-1g
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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SU11274 (PKI-SU11274) is a selective Met (c-Met) inhibitor with IC50 of 10 nM in cell-free assays no effects on PGDFR EGFR or Tie2 SU11274 induces autophagy apoptosis and cell cycle arrest
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC Hepatitis B Virus Core (128-140) | 160015-13-4 | 99.6% | 1406.63 | 1 MG
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Hepatitis B Virus Core (128-140) is a peptide derived from the hepatitis B virus core protein. This product is intended for research use only.
- High purity
- Solid, white to off-white appearance
- Soluble in water at ≥ 100 mg/mL
- Specific amino acid sequence
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC Radiprodil | 496054-87-6 | 99.16% | 397.40 | 50 MG
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Radiprodil is an orally active and selective NMDA NR2B antagonist. It is considered a potential therapeutic agent for the treatment of neuropathic pain and possibly other chronic pain conditions.
- Orally active and selective NMDA NR2B antagonist.
- Potential therapeutic agent for neuropathic pain and other chronic pain conditions.
- Has been shown to restore long-term potentiation (LTP) in the presence of certain amyloid-beta species (Aβ1-42, 3NTyr10-Aβ, and Aβ1-40) at 10 nM.
- Reverses the synaptic toxicity of 3NTyr-AβAβ1-40 and Aβ1-42.
- Can block NMDA currents in Mg2+ insensitive variants, with higher potency at pH 7.0 than at pH 7.6.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC Xininurad | 2365178-28-3 | 99.6% | 443.07 | 5 MG
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Xininurad (XNW3009) is a urate transporter (URAT) inhibitor. It appears as an off-white to light yellow solid.
- Urate transporter (URAT) inhibitor
- Solid appearance
- Off-white to light yellow color
- For research use only
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Selleck Chemical LLC Cynarin S3301-1mg
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Cynarin (Cynarine) is an artichoke phytochemical that possesses a variety of pharmacological features including free-radical scavenging antioxidant antihistamic and antiviral activities Cynarin blocks the interaction between the CD28 of T-cell receptor and CD80 of antigen presenting cells Cynarin triggers Nrf2 nuclear translocation restores the balance of glutathione (GSH) and reactive oxygen species (ROS) and inhibits mitochondrial depolarization
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Medchemexpress LLC HIF-2α agonist 2 | 2750141-15-0 | C13H8Br2N2O2S | 10MM/1ML
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HIF-2α agonist 2 is a chemical compound targeting HIF/HIF Prolyl-Hydroxylase. It is non-cytotoxic against 786-O-HRE-Luc cells and can be used for oxygen metabolism research. This compound is supplied as a solid.
- Targets HIF/HIF Prolyl-Hydroxylase
- Suitable for oxygen metabolism research
- Non-cytotoxic against 786-O-HRE-Luc cells
- Has an EC50 value of 1.68 μM at the dose of 20 μM
- Supplied as a solid
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Medchemexpress LLC GelMA, 60% methacrylation | 2280018-77-9 | 65% | 100 MG
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GelMA, 60% methacrylation | 2280018-77-9 | 65% | 100 MG
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Medchemexpress LLC NecroIr1 | 98.5% | 823.36 | 1 ML
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NecroIr1 is an iridium(III) complex that acts as a necroptosis inducer in Cisplatin-resistant lung cancer cells (A549R). It accumulates selectively in mitochondria, causing oxidative stress and a decrease in mitochondrial membrane potential (MMP). NecroIr1 activates receptor-interacting serine-threonine kinase 3 (RIPK3) and Mixed Lineage Kinase (MLKL), and regulates CDK4 expression.
- Accumulates over 90% in mitochondria
- Increases ROS generation and causes a loss of mitochondrial membrane potential
- Activates necroptosis proteins and increases phosphorylation of RIPK1 and RIPK3
- Induces necroptosis by arresting cell cycle at G0/G1
- Inhibits A549R cell proliferation
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Medchemexpress LLC CD3D-CD3E Heterodime 50ug | 50ug
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The CD3D protein is an important component of the TCR-CD3 complex on T lymphocytes and is critical for adaptive immune responses After APC activates TCR CD3D together with CD3E CD3G and CD3Z transmits signals through ITAM and activates downstream pathways CD3D-CD3E Heterodimer Protein Rhesus Macaque (HEK293 hFc) is a recombinant protein dimer complex containing Rhesus Macaque-derived CD3D-CD3E Heterodimer protein expressed by HEK293 with N-hFc
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Medchemexpress LLC Topovale (ARC-111) | 500214-53-9 | 99.9% | 421.45 | C23H23N3O5 | 50 MG
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Topovale (ARC-111) is a potent topoisomerase I inhibitor used in preclinical research to induce reversible TOP1 cleavage complexes and cause low nanomolar cytotoxicity in cancer cell models.
- Potent topoisomerase I inhibitor with low nanomolar cytotoxicity.
- High reported purity (99.94%).
- Molecular formula C23H23N3O5; molecular weight 421.45.
- Soluble in DMSO: 4.03 mg/mL (adjust pH to 2 with TFA; ultrasonic).
- Powder stable at -20°C for up to 3 years; limited stability in solvent.
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Medchemexpress LLC Methylstat | 1310877-95-2 | C28H31N3O6 | 25 MG
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Methylstat is a potent inhibitor of histone demethylases, showing anti-proliferative activity with low cytotoxicity. It promotes apoptosis and cell cycle arrest at the G0/G1 phase, while also increasing p53 and p21 protein expression. This compound inhibits angiogenesis induced by various cytokines, making it a valuable chemical probe for angiogenesis research.
- Potent histone demethylases inhibitor
- Exhibits anti-proliferative activity with low cytotoxicity
- Induces apoptosis
- Induces cell cycle arrest at the G0/G1 phase
- Increases the expression of p53 and p21 protein levels
- Inhibits angiogenesis induced by various cytokines
- Can be utilized as a chemical probe to study its role in angiogenesis
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Cayman Chemical Scriptaid Inhibitors
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An HDAC inhibitor that has an optimal effective concentration of 6-8 μM in a cell-based assay, is less toxic than trichostatin A, and works in a wide variety of biological systems; induces cell cycle arrest in cancer cells in vitro and in vivo; facilitates the cloning of inbred mouse strains produced by somatic cell nuclear transfer
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Medchemexpress LLC TRF1-TIN2 PPI-IN-1 | 374.41 | 5 MG
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TRF1-TIN2 PPI-IN-1 is an inhibitor of the TRF1-TIN2 interaction. It binds to the TRFH domain of TRF1 and competitively inhibits the binding of the TIN2 peptide. This compound disrupts the interaction between TRF1 and TIN2 by occupying the hotspot region of the binding interface. It can expel TRF1 from the shelterin complex.
- Disrupts TRF1-TIN2 interaction
- Binds to TRFH domain of TRF1
- Competitively inhibits TIN2 peptide binding
- Can be used to study shelterin-related cancers
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Medchemexpress LLC Acy-775 | 1375466-18-4 | 99.7% | 330.36 | 100 MG
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ACY-775 is a potent and selective inhibitor of histone deacetylase 6 (HDAC6) with an IC50 of 7.5 nM. It also inhibits metallo-β-lactamase domain-containing protein 2 (MBLAC2). Treatment with ACY-775 enhances the acetylation of α-tubulin, while histone acetylation remains unaltered.
- Potent and selective inhibitor of HDAC6
- Enhances acetylation of α-tubulin
- Increases motility and total number of mitochondria within neurites in DRG neurons
- Rapid elimination from plasma (half-life of 12 min)
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Medchemexpress LLC Iriflophenone | 52591-10-3 | 5 MG
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Iriflophenone, isolated from Aquilaria sinensis, stimulates MCF-7 and T-47D human breast cancer cell proliferation. This product is for research use only and not sold to patients.
- Purity: 98.05%
- Molecular weight: 246.22
- Formula: C13H10O5
- Appearance: Solid
- Color: White to yellow
- Structure classification: Phenols, Polyphenols
- Initial source: Plants (Thymelaeaceae, Aquilaria sinensis (Lour.) Spreng.; Iridaceae, Belamcanda chinensis (Linn.) Redouté)
- Solubility (In Vitro): DMSO: 250 mg/mL (1015.35 mM; requires ultrasonic)
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